Blood biomarkers of Alzheimer's disease

The partner laboratory of the Centre Médical Pasteur offers the measurement of the biomarkers involved in Alzheimer's disease. In blood: phosphorylated Tau protein 217 (pTau217), amyloid beta 1-42 peptide and the pTau217 / amyloid beta 1-42 ratio. In cerebrospinal fluid, collected by lumbar puncture: pTau181, total Tau, amyloid beta 1-42 and 1-40. These markers reflect the two characteristic processes of the disease, amyloid deposits and the accumulation of Tau protein, and their abnormalities can appear several years before the first symptoms. The blood assay, simple and non-invasive, makes this biological work-up much more accessible; the pTau217 / amyloid beta 1-42 ratio is today one of the best-performing blood markers, with strong agreement with amyloid imaging. These tests are part of a specialised diagnostic approach, prescribed by a neurologist or geriatrician, in a person with memory problems or wishing an early assessment of their risk. They are performed under strict pre-analytical conditions (rapid centrifugation, cold storage), guaranteed by the laboratory's workflow.